Indications and symptoms of overdosage array from moderate despair of your central anxious process and cardiovascular technique to profound hypotension, >respiratory depression, and unconsciousness.
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The appropriate intravenous administration of this product is well-tolerated, but use of the route is just not without some hazard. Not for subcutaneous administration.
If necessary, promethazine hydrochloride (promethazine hydrochloride injection) with a lowered dose of analgesic could be repeated a few times at four-hour intervals in the course of a normal labor. A maximum complete dose of 100 mg of promethazine hydrochloride (promethazine hydrochloride injection) could possibly be administered all through a 24-hour period of time to people in labor.
Will it have an effect on my contraception? Promethazine does not have an affect on any kind of contraception, including the put together pill and unexpected emergency contraception.
Medication protection Inform your health practitioner or pharmacist if you're taking any other medicines, which includes herbal medicines, vitamins or supplements.
Promethazine Hydrochloride Tablets, USP are contraindicated for use in pediatric people a lot less than two several years of age. Promethazine is contraindicated in comatose point out, As well as in people today identified to be hypersensitive or to possess experienced an idiosyncratic reaction to promethazine or to other phenthiazines.
Liquid medicines made up of promethazine arrive with a plastic syringe or spoon to assist you to measure out the correct dose.
Codeine may additionally present the chance of deadly overdose with prolonged abuse. In accordance with the National Institute On Drug Abuse (NIDA), “when abused, promethazine-codeine cough syrup offers a high chance of fatal overdose resulting from its effect of suppressing the central anxious process, which can slow or end the guts and lungs.
The management of NMS should really incorporate one) speedy discontinuation of promethazine hydrochloride, antipsychotic drugs, if any, and other drugs not essential to concurrent therapy, 2) intensive symptomatic treatment and professional medical checking, and 3) treatment of any concomitant major health-related complications for which precise treatments can be found. There's no common settlement about precise pharmacological treatment regimens for uncomplicated NMS. Considering that reoccurrences of NMS happen to be claimed with phenothiazines, the reintroduction of promethazine hydrochloride needs to be diligently considered.
Should you be prescribed this medication on a regular schedule and miss a dose, take it once you don't forget. If it is near time of the next dose, skip the skipped dose. Take your up coming dose at the frequent time. Tend not to double the dose to catch up.
Investigate has also identified phenothiazines as being a potential reason behind congenital malformations in a single analyze, but other research attest to their security. Promethazine is classified as category C because of the FDA. Alternative therapies may very well be indicated prior to promethazine, considering the risks towards the fetus and adverse effects within the mother.[10]
There isn't any tested successful management of this ailment right after it takes place, Though sympathetic block and heparinization are generally utilized in the course of the acute management as a result of final results of animal experiments with other regarded arteriolar irritants. Aspiration click here of dark blood doesn't preclude intra-arterial needle placement, simply because blood is discolored on Call with promethazine hydrochloride (promethazine hydrochloride injection) . Utilization of syringes with rigid plungers or of tiny bore needles may possibly obscure usual arterial backflow if This really is relied upon by yourself.
Ahead of working with this medication, Females of childbearing age ought to chat with their health practitioner(s) with regard to the risks and Advantages. Tell your physician In case you are pregnant or Consider you might be pregnant. In the course of pregnancy, this medication is just not advisable. It might marginally boost the danger of birth defects if used throughout the first two months of pregnancy. Also, applying it for just a long time or in high doses near the predicted delivery date may perhaps damage the unborn baby.